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KMID : 0381219710030080525
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Journal of RIMSK
1971 Volume.3 No. 8 p.525 ~ p.558
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EXPERIENCES WITH ORGAN TRANSPLANTATION IN THE RAT
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이선
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Abstract
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The involvement of the pancreas in carbohydrate metabolism has long been known, but the Perplexity of total pancreatic function probably delayed complete understanding of its endocrine role. Still, the exocrine role of the pancreas was more obvious and was, therefore, extensively long before insulin was isolated. The following are discussed briefly in chapter: physiological effect of total pancreatectomy, discovery of insulin, methods of preventing diabetes mellitus aside from insulin, survey of the literature related to pancreatic conditions and partial and total pancreatic transplantations. Effect of Pancreatic Duct Ligation or Pancreatectomy
Arnozan and Vaillard (1884) ligated the pancreatic duct in rabbits and found that within hours the ducts became dilated. In addition, the epithelial cells began to degenerate, and there were protoplasmic changes in the acinous cells. On the seventh day, round cell infiltration began and by the fourteenth day, the parenchyma was mostly replaced by fibrous tissue. However, von Mering and ´Minkowsky (1889) observed that totally pancreatectomized dogs developed hyperglycemia which uniformly led to death if not treated. Sscobolew (1902) further observed that if the pancreatic duct were ligated, pancreatic atrophy would result,but that no glucosuria occurred. In a long-term, follow-up study (30-120 days), he noticed destruction of the acini with preservation of the islets.
MacCallum (1909) clearly described that "The pancreas has a complicated structure and it seems clear that its functions are manifold, for on the one hand by its secretions, which are poured into the intestine, it plays an extremely prominent role in the preparation of all classes of food for absorption, while on the other hand there still remain the functions which
we can see so obscurely in their relation to general metabolism and which are apparently quite independent of this external or intestinal secretion´. MacCallum´s three-stage operation on the pancreas to prove that there is internal secretion by the pancreas is worth mentioning. One of the two branches of the pancreas, constituting rather more than one-third of the whole gland in the dog, was separated from the rest by the passage of two ligatures about the gland, which was cut through between them. These ligatures of black silk were intended.
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